Indomethacin inhibition of glutathione S-transferases
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چکیده
منابع مشابه
Indomethacin inhibition of glutathione S-transferases.
Indomethacin inhibited rat liver glutathione S-transferases (EC 2.5.1.18). Its inhibition was non-competitive with respect to 3,4-dichloronitrobenzene with an apparent Ki of 5.3 X 10(-5) M and uncompetitive with respect to glutathione with an apparent Ki of 4.0 X 10(-5) M. 4-Chlorobenzoic acid and 5-methoxy-2-methylindole-3-acetic acid, two metabolites of indomethacin, were weak inhibitors of t...
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Class-Pi of glutathione s-transferases (GST-Pi) is the specific form of GSTs that are known to participate particularly in the mechanisms of resistance to drugs and carcinogens. This class of the enzyme is referred to as class-P or class-Pi or class π. The accepted terminology in this review article is class-Pi. In this article following a brief description of identified molecular forms of GSTs...
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ژورنال
عنوان ژورنال: Biochemical and Biophysical Research Communications
سال: 1983
ISSN: 0006-291X
DOI: 10.1016/0006-291x(83)91714-x